Protein name:
Galactocerebrosidase (GALCERase) ;
Alternative:
Galactosylceramidase ;Galactocerebroside beta-galactosidase ;Galactosylceramide beta-galactosidase ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Subcellular Location:
Lysosome
Protein Attributes:
50:
MANSQPKASQ | QRQAKVMTAA | AGSASRVAVP | LLLCALLVPG | GAYVLDDSDG |
100:
LGREFDGIGA | VSGGGATSRL | LVNYPEPYRS | EILDYLFKPN | FGASLHILKV |
150:
EIGGDGQTTD | GTEPSHMHYE | LDENYFRGYE | WWLMKEAKKR | NPDIILMGLP |
200:
WSFPGWLGKG | FSWPYVNLQL | TAYYVVRWIL | GAKHYHDLDI | DYIGIWNERP |
250:
FDANYIKELR | KMLDYQGLQR | VRIIASDNLW | EPISSSLLLD | QELWKVVDVI |
300:
GAHYPGTYTV | WNAKMSGKKL | WSSEDFSTIN | SNVGAGCWSR | ILNQNYINGN |
350:
MTSTIAWNLV | ASYYEELPYG | RSGLMTAQEP | WSGHYVVASP | IWVSAHTTQF |
400:
TQPGWYYLKT | VGHLEKGGSY | VALTDGLGNL | TIIIETMSHQ | HSMCIRPYLP |
450:
YYNVSHQLAT | FTLKGSLREI | QELQVWYTKL | GTPQQRLHFK | QLDTLWLLDG |
500:
SGSFTLELEE | DEIFTLTTLT | TGRKGSYPPP | PSSKPFPTNY | KDDFNVEYPL |
550:
FSEAPNFADQ | TGVFEYYMNN | EDREHRFTLR | QVLNQRPITW | AADASSTISV |
600:
IGDHHWTNMT | VQCDVYIETP | RSGGVFIAGR | VNKGGILIRS | ATGVFFWIFA |
650:
NGSYRVTADL | GGWITYASGH | ADVTAKRWYT | LTLGIKGYFA | FGMLNGTILW |
684:
KNVRVKYPGH | GWAAIGTHTF | EFAQFDNFRV | EAAR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Dog
ELISA Kit for Mouse GALCERase
ELISA Kit for Mouse GALCERase
ELISA Kit for Mouse GALCERase
CLIA Kit for Mouse GALCERase
CLIA Kit for Mouse GALCERase
CLIA Kit for Mouse GALCERase
Polyclonal Antibody for Mouse GALCERase
Polyclonal Antibody for Mouse GALCERase
Polyclonal Antibody for Mouse GALCERase
Monoclonal Antibody for Mouse GALCERase
Monoclonal Antibody for Mouse GALCERase
Monoclonal Antibody for Mouse GALCERase
Protein for Mouse GALCERase
Protein for Mouse GALCERase
Protein for Mouse GALCERase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease."
Sakai N.
,
Inui K.
,
Tatsumi N.
,
Fukushima H.
,
Nishigaki T.
,
Taniike M.
,
Nishimoto J.
,
Tsukamoto H.
,
Yanagihara I.
,
Ozono K.
,
Okada S.
J. Neurochem.66:1118-1124(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY;ROLE IN DISEASE
strain :
C57BL/6J .
tissue :
Testis .
2.
"Genomic organization of the mouse galactocerebrosidase (GALC) gene."
Luzi P.
,
Victoria T.
,
Wenger D.A.
Submitted (1997-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
,
Frith M.C.
,
Maeda N.
,
Oyama R.
,
Ravasi T.
,
Lenhard B.
,
Wells C.
,
Kodzius R.
,
Shimokawa K.
,
Bajic V.B.
,
Brenner S.E.
,
Batalov S.
,
Forrest A.R.
,
Zavolan M.
,
Davis M.J.
,
Wilming L.G.
,
Aidinis V.
,
Allen J.E.
,
Ambesi-Impiombato A.
,
Apweiler R.
,
Aturaliya R.N.
,
Bailey T.L.
,
Bansal M.
,
Baxter L.
,
Beisel K.W.
,
Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
,
Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
,
Futaki S.
,
Gariboldi M.
,
Georgii-Hemming P.
,
Gingeras T.R.
,
Gojobori T.
,
Green R.E.
,
Gustincich S.
,
Harbers M.
,
Hayashi Y.
,
Hensch T.K.
,
Hirokawa N.
,
Hill D.
,
Huminiecki L.
,
Iacono M.
,
Ikeo K.
,
Iwama A.
,
Ishikawa T.
,
Jakt M.
,
Kanapin A.
,
Katoh M.
,
Kawasawa Y.
,
Kelso J.
,
Kitamura H.
,
Kitano H.
,
Kollias G.
,
Krishnan S.P.
,
Kruger A.
,
Kummerfeld S.K.
,
Kurochkin I.V.
,
Lareau L.F.
,
Lazarevic D.
,
Lipovich L.
,
Liu J.
,
Liuni S.
,
McWilliam S.
,
Madan Babu M.
,
Madera M.
,
Marchionni L.
,
Matsuda H.
,
Matsuzawa S.
,
Miki H.
,
Mignone F.
,
Miyake S.
,
Morris K.
,
Mottagui-Tabar S.
,
Mulder N.
,
Nakano N.
,
Nakauchi H.
,
Ng P.
,
Nilsson R.
,
Nishiguchi S.
,
Nishikawa S.
,
Nori F.
,
Ohara O.
,
Okazaki Y.
,
Orlando V.
,
Pang K.C.
,
Pavan W.J.
,
Pavesi G.
,
Pesole G.
,
Petrovsky N.
,
Piazza S.
,
Reed J.
,
Reid J.F.
,
Ring B.Z.
,
Ringwald M.
,
Rost B.
,
Ruan Y.
,
Salzberg S.L.
,
Sandelin A.
,
Schneider C.
,
Schoenbach C.
,
Sekiguchi K.
,
Semple C.A.
,
Seno S.
,
Sessa L.
,
Sheng Y.
,
Shibata Y.
,
Shimada H.
,
Shimada K.
,
Silva D.
,
Sinclair B.
,
Sperling S.
,
Stupka E.
,
Sugiura K.
,
Sultana R.
,
Takenaka Y.
,
Taki K.
,
Tammoja K.
,
Tan S.L.
,
Tang S.
,
Taylor M.S.
,
Tegner J.
,
Teichmann S.A.
,
Ueda H.R.
,
van Nimwegen E.
,
Verardo R.
,
Wei C.L.
,
Yagi K.
,
Yamanishi H.
,
Zabarovsky E.
,
Zhu S.
,
Zimmer A.
,
Hide W.
,
Bult C.
,
Grimmond S.M.
,
Teasdale R.D.
,
Liu E.T.
,
Brusic V.
,
Quackenbush J.
,
Wahlestedt C.
,
Mattick J.S.
,
Hume D.A.
,
Kai C.
,
Sasaki D.
,
Tomaru Y.
,
Fukuda S.
,
Kanamori-Katayama M.
,
Suzuki M.
,
Aoki J.
,
Arakawa T.
,
Iida J.
,
Imamura K.
,
Itoh M.
,
Kato T.
,
Kawaji H.
,
Kawagashira N.
,
Kawashima T.
,
Kojima M.
,
Kondo S.
,
Konno H.
,
Nakano K.
,
Ninomiya N.
,
Nishio T.
,
Okada M.
,
Plessy C.
,
Shibata K.
,
Shiraki T.
,
Suzuki S.
,
Tagami M.
,
Waki K.
,
Watahiki A.
,
Okamura-Oho Y.
,
Suzuki H.
,
Kawai J.
,
Hayashizaki Y.
more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
NOD .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 40-684 IN COMPLEX WITH GALACTOSE;ACTIVE SITE;GLYCOSYLATION AT ASN-300; ASN-379; ASN-403 AND ASN-558;DISULFIDE BOND